SUCCESS IN CLINICAL LABORATORY SCIENCE PDF

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Success In Clinical Laboratory Science Pdf

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It seemed to work much like the communication system used by bacteria — quorum sensing — to share information about cell density and adjust the population accordingly.

Yet it was the first time anyone had demonstrated molecular messaging of this kind in viruses. And it fitted into an emerging picture of viruses as much more sophisticated social agents than scientists had given them credit for. Virologists have long studied their subjects in isolation, targeting cells with just a single viral particle.

The implication is that researchers might have been going about their experiments all wrong.

Learning the language behind these viral interactions could inform the design of new treatments for cancer and nasty superinfections. The relevance to basic biology was missed. Viruses known as phages green can better infect cells like this bacterium orange when they cooperate and communicate.

They often took place between different viral strains that had a shared interest in boosting their own reproductive chances. But the molecular basis of those cooperative traits — the method of communication — had largely remained elusive. Those technical details, reported in five papers 3 — 7 over the past nine months, helped to explain exactly how the short peptides Sorek discovered influence viral decision-making. For Marina, however, this is just the start of the story: he suspects that the communication system probably serves many more functions.

Success! in Clinical Laboratory Science

His team has now found at least 15 different types of phage, all of which can infect soil microbes and use some sort of short peptide to communicate 8. The viral chit-chat thus seems to have evolved to allow communication only between close relatives. Phages might speak only to their own kind, but they can also listen in on other languages. Molecular biologist Bonnie Bassler and her graduate student Justin Silpe have found that viruses can use quorum-sensing chemicals released by bacteria to determine when best to start multiplying — and murdering 9.

This molecular snooping occurs naturally in phages that infect the bacterium responsible for cholera, Vibrio cholerae. The viruses in effect became programmable assassins that could be made to kill off any bacterium — at will and on demand. For the greater good Some viral cooperation seems to verge on altruism.

Research, new experiences motivate incoming AHA president

Two independent groups reported last year that some phages act selflessly to overcome the viral countermeasures of Pseudomonas bacteria 10 , The first wave of viruses attacked the cells, killing themselves but also weakening the bacteria. The initial bombardment paved the way for others to conquer the microbial foe.

In follow-up work, Westra and his postdoc Anne Chevallereau demonstrated how phages lacking these anti-CRISPR proteins can exploit the cooperative offerings of others that do To Westra, that shows the potentially far-reaching consequences of altruistic behaviours among viruses. Take vesicular stomatitis virus VSV , which mainly infects farm animals, but can cause a flu-like illness in humans, too.

No one is sure yet how this cooperative evasion is happening, but the work highlights how crucial altruism can be for the success of VSV.

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